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There are over 100 animals at the T.I.G.E.R.S. preserve in Myrtle Beach, S.C., a place that offers visitors firsthand interaction with wild animals.

Brotherly Bonds

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Dogs may be man&rsquo;s best friend, but their extraordinary chumminess and dogged loyalty extend to countless other animals as well. Here are true stories and behind-the-scene events of some of the most uncanny canine acquaintances from around the world.

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At Columbus Zoo and Aquarium in Powell, Ohio, a Labrador retriever named Carlisle is friends with a pack of cheetahs, an equally social species.

Fast Friends

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Friendship reaches new heights when a hunting dog makes friends with a creature who could have been his prey, and a husky forms an alliance with a cat.

Colossal Comrades

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Born with a birth defect, rescue dog Roo's front legs never fully develop, but when sent to Canada, she strikes a strong bond with another rescue dog.

Caretaker Couples

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At an ecotourism zoo in Florida, an energetic dog is put in with another spirited playmate, a tiger cub who was rejected by his mother at birth.

Perfect Pairs

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The Lenihans' family dog Hondo, a German shepherd mixed breed, has no shortage of playmates but chooses a solitary coati-mundi to be his best friend.

Rowdy Roommates

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After failing to find a feisty 10-year-old miniature horse named Spanky a friend, a brave little Jack Russell terrier named Dally finds a soft spot.

The Tale of Two Tails

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More outgoing than most bunnies, Pepper the rabbit falls in love when she meets an adorable little friend, a Cavalier King Charles spaniel named Lola.

Bouncing Buddies

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Maine coon cat Pook holds his own with his group of dog brothers, from going outside to play to even insisting on eating the same food as the dogs.

Part of the Pack

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Pickles, the potbellied piglet, becomes extremely sick, but after a remarkable recovery, his owners find him a friend in a French bulldog called Dill.

Dog's Best Friend: Cutest Canine Companions

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